For coloring rows, make sure that you first check how to use conditional formatting (highlighting) in this documentation section.
For changing the general design look and feel of the table elements check the plugin configuration page.
By default each column in wpDataTables has same CSS classes applied and has a same look, but you can always style and color the columns as you need.
Sometimes it is handy to have right-align for numeric columns, especially if you have large numbers in your table. This feature is supported out-of-the-box – to enable it you’d just need to tick the “Align numbers to the right” checkbox in the wpDataTables settings page – then all of the numbers in all tables will be right-aligned.
Coloring columns is also very simple – there is a color picker in each column settings block: